Browsing by Subject "calcium"
Now showing items 1-7 of 7
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(2006-04-05)Department: PhysicsThe dissertation describes the design and application of the Nanophysiometer, a microfluidic network that is combined with a thin film microelectrode array to study force – excitation coupling in single cardiac myocytes. ...
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(2012-08-06)Department: Chemical and Physical BiologyThe structural analysis of the sodium-calcium exchanger NCX1.1 is presented in this thesis. I explore the background information and previous research detailing NCX1.1 and its mechanism. I also explain some of the technical ...
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(2019-04-08)Department: Biological SciencesOver the years, periodic innovations in fluorescence microscopic technologies have afforded researchers a more sophisticated understanding of the inner workings of the cell. These methods are valuable but drawbacks include ...
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(2017-09-14)Department: Cell and Developmental BiologyIn normal epithelial wound repair, cells across an epithelial sheet begin a coordinated process of re-epithelialization within minutes of wounding. These coordinated behaviors are driven by a calcium wave, a rise in ...
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(2018-05-21)Department: PharmacologyMutations in lamin A/C (LMNA) are the second most common contributor to genetic cases of dilated cardiomyopathy (DCM). Despite the autosomal-dominant inheritance of LMNA DCM, gene-targeted mouse models of LMNA DCM show ...
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(2005-08-12)Department: BiochemistryThe function of the human cardiac voltage-gated sodium channel hH1 is regulated in part by an EF-hand in its C-terminal cytoplasmic domain. The binding of calcium to the EF-hand results in calmodulin-independent, ...
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(2014-08-04)Department: Biomedical EngineeringSubarachnoid hemorrhage (SAH) affects approximately 30,000 people each year and accounts for 1-7% of all strokes. Spontaneous SAH occurs due to the rupture of a cerebral aneurysm. SAH is characterized primarily by loss of ...