Browsing by Subject "chromatin"

Now showing items 1-7 of 7

    • ATP Citrate Lyase and mitochondrial membrane potential regulate hematopoietic cell fate and function 
      Greenwood, Dalton Lee; 0000-0003-0905-5211 (2023-03-23)
      Department: Molecular Pathology & Immunology
      In addition to their role in bioenergetic homeostasis, mitochondria are increasingly appreciated as regulators of hematopoietic cell fate and function. Here, we demonstrate the role of ATP citrate lyase (ACLY) on murine ...
    • Elucidation of the Biological Function of the RPC Family Ubiquitin Ligase Asr1 
      McCann, Tyler Scott (2016-01-13)
      Department: Cell and Developmental Biology
      Proper regulation of gene transcription is an essential process for any cell. Failure to precisely control the procedure of transcription can lead to developmental defects, disease, and even death. Within the last 20 years, ...
    • Pharmacological WDR5 WIN site inhibition as an anti-leukemia target 
      Aho, Erin Renee (2019-05-16)
      Department: Cell and Developmental Biology
      The epigenetic regulator WDR5 is a promising therapeutic target in leukemias expressing oncogenic translocations of the MLL1 histone methyltransferase gene. Despite the validation of the WIN site of WDR5 as a pharmacological ...
    • Role of Host Cell Factor-1 in MYC-driven gene expression and tumorigenesis 
      Popay, Tessa Mary; 0000-0002-4694-8804 (2020-12-06)
      Department: Cell & Developmental Biology
      The oncoprotein transcription factor MYC is a major driver of malignancy and a highly-validated target for development of anti-cancer therapies. It has, however, proven challenging to inhibit MYC directly. Novel strategies ...
    • Targeting WDR5: A WINning Anti-Cancer Strategy? 
      Aho, Erin R.; Weissmiller, April M.; Fesik, Stephen W.; Tansey, William P. (EPIGENETICS INSIGHTS, 2019-07-18)
      WDR5 is a component of multiple epigenetic regulatory complexes, including the mixed lineage leukemia (MLL)/SET complexes that deposit histone H3 lysine 4 methylation. Inhibitors of an arginine-binding cavity in WDR5, known ...
    • The role of the ubiquitin-proteasome system in Gcn4 target gene transcription 
      Howard, Gregory Caleb (2016-08-31)
      Department: Cell and Developmental Biology
      The ubiquitin–proteasome system (UPS) influences gene transcription in multiple ways. One way in which the UPS impacts transcription centers on transcriptional activators, the function of which can be stimulated by components ...
    • The WDR5 interaction network 
      Guarnaccia, Alissa duPuy; 0000-0003-4195-2158 (2021-02-10)
      Department: Cell & Developmental Biology
      WDR5 is a conserved WD40-repeat protein that rose to prominence through its role in epigenetic complexes, including the KMT2 (MLL/SET) enzymes that deposit histone H3 lysine 4 methylation and the non-specific lethal complex ...