Browsing by Subject "colorectal cancer"
Now showing items 1-20 of 23
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(2010-04-12)Department: Cell and Developmental BiologyColorectal cancer is the second most lethal, non-cutaneous epithelial cancer in the United States. Metastasis contributes to the majority of cancer-related deaths in this disease. Metastasis closely resembles the ...
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(2008-04-07)Department: Cancer BiologyColon cancer progression is frequently characterized by activating mutations in Ras and emergence of the tumor promoting effects of TGF-beta signaling. Ras-inducible rat intestinal epithelial cells (RIE:iRas) undergo a ...
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(2013-04-15)Department: Biomedical EngineeringBiomarkers that predict response to targeted therapy in oncology are an essential component of personalized medicine. With an increasing reliance on molecularly targeted therapies, there remains an equally critical challenge ...
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(2017-11-21)Department: EpidemiologyPrevious pharmacogenetics studies of 5-fluorouracil (5-FU) have focused on coding variants, and only four of these variants showed consistent association, which explained a small fraction of the heritability of 5-FU-associated ...
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(2017-04-04)Department: Cell and Developmental BiologyApico-basolateral polarity is a fundamental property of epithelial cells, and its loss is a hallmark of colorectal cancer (CRC). Role(s) for lateral integrins in this polarization process and the consequences of their ...
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(2020-01-02)Department: Biological SciencesColorectal cancer (CRC) cells release protein-laden extracellular vesicles (EVs) that can alter the tumor microenvironment and spread drug resistance. I compared long RNAs of cells and matched EVs from isogenic CRC cell ...
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(2016-11-15)Department: BiochemistryBIOCHEMISTRY Oncogenic KRAS and BRAF Drive Metabolic Reprogramming in Colorectal Cancer Josiah Ewing Hutton, III. Dissertation under the direction of Professor Daniel C. Liebler Analysis of cancer cells that have ...
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(2017-03-27)Department: Cell and Developmental BiologyThe Wnt pathway is a highly-conserved pathway that controls many developmental processes and is mutated in many human diseases (e.g., cancer). The tumor suppressor adenomatous polyposis coli (APC) is a critical negative ...
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(2023-07-20)Department: Cancer BiologyAlthough selenium deficiency correlates with colorectal cancer (CRC) risk, the roles of the selenium-rich antioxidant selenoprotein P (SELENOP) in CRC remain unclear. In this study, we defined SELENOP’s contributions to ...
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(2023-07-20)Department: Cancer BiologyAlthough selenium deficiency correlates with colorectal cancer (CRC) risk, the roles of the selenium-rich antioxidant selenoprotein P (SELENOP) in CRC remain unclear. In this study, we defined SELENOP’s contributions to ...
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(2023-07-20)Department: Cancer BiologyAlthough selenium deficiency correlates with colorectal cancer (CRC) risk, the roles of the selenium-rich antioxidant selenoprotein P (SELENOP) in CRC remain unclear. In this study, we defined SELENOP’s contributions to ...
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(2023-07-20)Department: Cancer BiologyAlthough selenium deficiency correlates with colorectal cancer (CRC) risk, the roles of the selenium-rich antioxidant selenoprotein P (SELENOP) in CRC remain unclear. In this study, we defined SELENOP’s contributions to ...
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(2023-07-20)Department: Cancer BiologyAlthough selenium deficiency correlates with colorectal cancer (CRC) risk, the roles of the selenium-rich antioxidant selenoprotein P (SELENOP) in CRC remain unclear. In this study, we defined SELENOP’s contributions to ...
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(2023-07-20)Department: Cancer BiologyAlthough selenium deficiency correlates with colorectal cancer (CRC) risk, the roles of the selenium-rich antioxidant selenoprotein P (SELENOP) in CRC remain unclear. In this study, we defined SELENOP’s contributions to ...
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(2023-07-20)Department: Cancer BiologyAlthough selenium deficiency correlates with colorectal cancer (CRC) risk, the roles of the selenium-rich antioxidant selenoprotein P (SELENOP) in CRC remain unclear. In this study, we defined SELENOP’s contributions to ...
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(2023-07-20)Department: Cancer BiologyAlthough selenium deficiency correlates with colorectal cancer (CRC) risk, the roles of the selenium-rich antioxidant selenoprotein P (SELENOP) in CRC remain unclear. In this study, we defined SELENOP’s contributions to ...
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(2023-07-20)Department: Cancer BiologyAlthough selenium deficiency correlates with colorectal cancer (CRC) risk, the roles of the selenium-rich antioxidant selenoprotein P (SELENOP) in CRC remain unclear. In this study, we defined SELENOP’s contributions to ...
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(2023-07-20)Department: Cancer BiologyAlthough selenium deficiency correlates with colorectal cancer (CRC) risk, the roles of the selenium-rich antioxidant selenoprotein P (SELENOP) in CRC remain unclear. In this study, we defined SELENOP’s contributions to ...
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(2023-07-20)Department: Cancer BiologyAlthough selenium deficiency correlates with colorectal cancer (CRC) risk, the roles of the selenium-rich antioxidant selenoprotein P (SELENOP) in CRC remain unclear. In this study, we defined SELENOP’s contributions to ...
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(2023-07-20)Department: Cancer BiologyAlthough selenium deficiency correlates with colorectal cancer (CRC) risk, the roles of the selenium-rich antioxidant selenoprotein P (SELENOP) in CRC remain unclear. In this study, we defined SELENOP’s contributions to ...