Browsing by Subject "endocytosis"

Now showing items 1-9 of 9

    • Cellular Role Of The Drosophila EFR3, Rolling Blackout (RBO) In Synaptic Transmission. 
      Vijayakrishnan, Niranjana (2010-03-29)
      Department: Neuroscience
      Rolling Blackout (RBO), a Drosophila EFR3 homolog, is an integral membrane protein predicted to be a lipase. A conditional temperature-sensitive (TS) mutant (rbots) displays paralysis following a 25-37oC temperature shift, ...
    • Defects in COG-Mediated Golgi Trafficking Alter Endo-Lysosoma System in Human Cells 
      D'Souza, Zinia; Blackburn, Jessica Bailey; Kudlyk, Tetyana; Pokrovskaya, Irina D.; Lupashin, Vladimir V. (FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 2019-07-03)
      The conserved oligomeric complex (COG) is a multi-subunit vesicle tethering complex that functions in retrograde trafficking at the Golgi. We have previously demonstrated that the formation of enlarged endo-lysosomal ...
    • Defects in COG-Mediated Golgi Trafficking Alter Endo-Lysosoma System in Human Cells 
      D'Souza, Zinia; Blackburn, Jessica Bailey; Kudlyk, Tetyana; Pokrovskaya, Irina; Lupashin, Vladimir V. (FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 2019-07-03)
      The conserved oligomeric complex (COG) is a multi-subunit vesicle tethering complex that functions in retrograde trafficking at the Golgi. We have previously demonstrated that the formation of enlarged endo-lysosomal ...
    • Defects in COG-Mediated Golgi Trafficking Alter Endo-Lysosoma System in Human Cells 
      Lupashin, Vladimir V.); D'Souza, Zinia; Blackburn, Jessica Bailey; Kudlyk, Tetyana; Pokrovskaya, Irina D. (FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 2019-07-03)
      The conserved oligomeric complex (COG) is a multi-subunit vesicle tethering complex that functions in retrograde trafficking at the Golgi. We have previously demonstrated that the formation of enlarged endo-lysosomal ...
    • Identification and characterization of cellular determinants of reovirus internalization. 
      Maginnis, Melissa Sue (2007-04-17)
      Department: Microbiology and Immunology
      Virus cell entry is a multi-step process that often requires independent receptors for attachment and internalization. Reovirus infection is initiated by attachment to cell-surface carbohydrate and junctional adhesion ...
    • Mechanism of Clostridium difficile Toxin A Entry into Host Cells 
      Chandrasekaran, Ramyavardhanee (2017-11-27)
      Department: Microbiology and Immunology
      Clostridium difficile infection affects a significant number of hospitalized patients in the United States. Two homologous exotoxins, TcdA and TcdB, are the major virulence factors in C. difficile pathogenesis. The toxins ...
    • Regulation of Wnt Receptor Activation by the Tumor Suppressor APC 
      Saito-Diaz, Vicente Kenyi (2017-03-27)
      Department: Cell and Developmental Biology
      The Wnt pathway is a highly-conserved pathway that controls many developmental processes and is mutated in many human diseases (e.g., cancer). The tumor suppressor adenomatous polyposis coli (APC) is a critical negative ...
    • Role of Cytoskeleton in Cholera Toxin Diffusion and Endocytosis 
      Day, Charles Asher (2013-04-19)
      Department: Molecular Physiology and Biophysics
      The plasma membrane is highly organized as a means to regulate various processes including sorting of cargo for endocytosis. However, the mechanisms responsible for this organization are poorly understood. The B subunit ...
    • The Regulation of Endocytosis by Snf1-related Kinases in Yeast 
      Tumolo, Jessica Marie (2019-06-20)
      Department: Cell and Developmental Biology
      Cellular homeostasis, a fundamental requirement for all living organisms, is maintained in part through endocytic downregulation. Endocytosis of nutrient transporters is regulated in response to changing environmental ...