Browsing by Subject "enzymology"
Now showing items 1-5 of 5
-
(2015-01-16)Department: PharmacologyPhospholipase D (PLD) is a ubiquitous enzyme found in prokaryotic and eukaryotic organisms that generates phosphatidic acid. A number of human bacterial pathogens produce PLD as virulence factors to promote infections. ...
-
(2011-02-21)Department: PharmacologyComplex II superfamily members catalyze two separate reactions in respiration: interconversion of fumarate and succinate in the soluble milieu and interconversion of quinol and quinone in the membrane. Electrons liberated ...
-
(2018-09-18)Department: BiochemistryThe preservation of DNA replication is requisite for cellular integrity and prevention of tumor formation and cell death. The Y-family DNA polymerases (Pol eta, kappa, iota, and REV1) are crucial in this process because ...
-
(2006-03-30)Department: PharmacologyIn mammalian cells, phospholipase D activity is tightly regulated by diverse cellular signals including hormones, neurotransmitters, and growth factors. Multiple signaling pathways converge upon phospholipase D to modulate ...
-
(2010-01-04)Department: PathologyThe studies in this dissertation defined the molecular mechanism of prothrombin (ProT) activation by a recently-identified Staphylococcus aureus exoprotein, von Willebrand factor-binding protein (VWbp). We demonstrated ...