Browsing by Subject "epigenetics"
Now showing items 1-8 of 8
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(2014-06-25)Department: Chemical and Physical BiologyThe methylation state of DNA is important for gene expression, gene imprinting, X-chromosome inactivation, and transposon silencing in mammals and plants. DNA methylation is established by methyltransferases to mark a ...
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Analyzing genome integrity during DNA replication using iPOND (isolation of Proteins On Nascent DNA) (2013-07-12)Department: BiochemistryThe in vivo analysis of dynamic events that protect genomic and epigenomic integrity during DNA replication has been a challenging task. The proteins that ensure the accurate inheritance of the genome act directly at ...
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ATP Citrate Lyase and mitochondrial membrane potential regulate hematopoietic cell fate and function (2023-03-23)Department: Molecular Pathology & ImmunologyIn addition to their role in bioenergetic homeostasis, mitochondria are increasingly appreciated as regulators of hematopoietic cell fate and function. Here, we demonstrate the role of ATP citrate lyase (ACLY) on murine ...
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(Aging Cell, 2019-08)CpG-related single nucleotide polymorphisms (CGS) have the potential to perturb DNA methylation; however, their effects on Alzheimer disease (AD) risk have not been evaluated systematically. We conducted a genome-wide ...
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(JOURNAL OF BIOLOGICAL CHEMISTRY, 2019-06-21)Mouse studies linking adropin, a peptide hormone encoded by the energy homeostasis-associated (ENHO) gene, to biological clocks and to glucose and lipid metabolism suggest a potential therapeutic target for managing diseases ...
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(2009-04-22)Department: NeuroscienceMammalian circadian rhythms are orchestrated by the suprachiasmatic nuclei (SCN) of the hypothalamus. The SCN are composed of circadian clock neurons but the mechanisms by which these neuronal oscillators encode circadian ...
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(2011-09-26)Department: Cancer BiologySynovial sarcoma (SS) is a rare but aggressive malignancy that is typically diagnosed in adolescents and young adults. These tumors are characterized by the presence of a specific chromosomal translocation t(X;18)(p11.2;q11.2) ...
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(2020-03-20)Department: Chemical & Physical BiologyThe hormone erythropoietin (Epo) is required for erythropoiesis, yet its molecular mechanism of action remains poorly understood. To investigate how Epo modulates the erythroid genome, I performed epigenetic profiling using ...