Browsing by Subject "extracellular matrix"
Now showing items 1-16 of 16
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(2018-07-30)Department: Biomedical EngineeringFracture resistance of bone depends on the hierarchical organization of its constituents, primarily the organic matrix, mineral, and water, and as such, requires characterization at multiple length-scales. The extracellular ...
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(2014-07-26)Department: Biomedical EngineeringAlthough extracellular matrix (ECM) composition and organization are considered important regulators of cardiomyocyte phenotype in vitro and in vivo, a causal relationship between the ECM structure and effect on maintenance ...
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(2012-08-31)Department: Cancer BiologyThese studies tested the hypothesis that cell-extracellular matrix (ECM) interactions promote the maturation of invadopodia to fully functional structures. I demonstrate that invadopodia-associated ECM degradation is ...
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(2016-12-05)Department: PathologyExtracellular matrix (ECM) functions as the insoluble scaffold of tissues that controls cellular behaviors and regulates environmental cues that are essential for many aspects of biology. Basement membranes (BMs) are ...
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(2014-11-18)Department: Biomedical EngineeringThe age-related risk of skeletal fracture is a significant problem in modern medicine, such that both hip fracture and osteoporotic fracture are listed in the World Health Organization top 12 sources of disease burden, ...
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(2017-02-03)Department: PhysicsClinical imaging and biopsies are major tools for cancer diagnosis. We explore whether serial imaging coupled with a mathematical model could test and refine patient specific forecasts for therapy outcomes. We first ...
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(2018-01-09)Department: Biological SciencesCancer-associated fibroblasts (CAFs) are major components of the carcinoma microenvironment that promote tumor progression. However, the mechanisms by which CAFs regulate cancer cell migration are poorly understood. In ...
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(2015-03-25)Department: Molecular Physiology and BiophysicsThe prevalence of type 2 diabetes has increased dramatically in parallel with excess caloric intake and sedentary lifestyles. Insulin resistance precedes the development of type 2 diabetes. The liver is a major insulin-responsive ...
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(2022-07-13)Department: Cancer BiologyIntegrins, the principal extracellular matrix (ECM) receptors of the cell, promote cell adhesion, migration, and proliferation, which are key events for cancer growth and metastasis. To date, most integrin-targeted cancer ...
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(2017-05-11)Department: Cancer BiologyIt was been well established that the Activin A signaling pathway plays a pivotal role in the developing, adult, and diseased organism, commonly acting as a growth inhibitor. Though prevalent in embryonic tissues, Activin ...
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(2011-01-31)Department: Cancer BiologyProstate cancer is the second most common form of cancer in men. Despite the alarming figures and decades of research, a cure still eludes prostate cancer patients. The morbidity associated with advanced prostate cancer ...
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(2019-08-01)Department: Chemical EngineeringTriple negative breast cancer (TNBC) is an aggressive subtype of breast cancer that lacks estrogen receptor, progesterone receptor, and HER2, making it difficult to treat with conventional medicine. One common form of ...
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(2019-02-28)Department: Cell and Developmental BiologyCollagens are the structural components of extracellular matrix (ECM), constituting over 30% of dry body weight in vertebrates. Despite their abundance, mechanisms regulating collagen secretion during tissue homeostasis ...
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(2009-04-21)Department: BiochemistryPhospholipase C-γ1 (PLC-γ1) mediates cell adhesion and migration through an undefined mechanism. Here, we examine the role of PLC-γ1 in cell-matrix adhesion in a hanging drop assay of cell aggregation. Plcg1 Null (-/-) ...
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(2010-09-01)Department: Cancer BiologyThe major goal of this thesis is to investigate the role of MT1-MMP in kidney development. Our results demonstrate that loss of MT1-MMP leads to a renal phenotype characterized by a moderate decrease in ureteric bud branching ...
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(2016-03-30)Department: Biological SciencesNon-muscle myosin II (MyoII) contractility is important to the regulation of many cellular processes, including migration. The small GTPase Rho has been shown to regulate MyoII contractility, but the role of other GTPases, ...