Browsing by Subject "factor XI"

Now showing items 1-3 of 3

    • A mechanism for exosite-mediated factor IX activation by factor XIa 
      Geng, Yipeng (2014-04-19)
      Department: Pathology
      Factor XI (FXI) is the zymogen of a protease (FXIa) that contributes to blood coagulation by activating factor IX (FIX). This thesis presents several novel observations regarding the structure and function of FXI that will ...
    • The molecular mechanism of factor IX activation by factor XIa 
      Smith, Stephen Bradford (2009-04-09)
      Department: Pathology
      Activation of coagulation factor IX is a pivotal reaction in the formation and maintenance of a fibrin clot. Factor IX is activated by two structurally unrelated enzymes; factor XIa of the intrinsic coagulation cascade and ...
    • The Role of Factor XI During Murine Polymicrobial Sepsis 
      Bane, Charles Edward Jr. (2016-11-21)
      Department: Pathology
      Sepsis is a systemic inflammatory response to infection. It is often accompanied by the pathologic production of thrombin, the key enzyme in blood plasma responsible for coagulation, and by contact activation, which is a ...