Browsing by Subject "p53"
Now showing items 1-8 of 8
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(2014-09-29)Department: NeuroscienceThe essential micronutrient manganese is enriched in brain, especially the basal ganglia. We sought to identify neuronal signaling pathways responsive to neurologically relevant manganese levels, as previous data suggested ...
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(2006-08-09)Department: Microbiology and ImmunologyMICROBIOLOGY AND IMMUNOLOGY CHARACTERIZATION OF AN AUTOIMMUNE GENE EXPRESSION SIGNATURE KEVIN MAAS Dissertation under the direction of Professor Thomas Aune Autoimmune diseases affect approximately 5% of the human ...
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(2009-06-08)Department: Biochemistryp73, a transcription factor that plays essential roles during development and tumor suppression, shares significant sequence identity with p53. However, p53 and p73 are regulated by different pathways, and p73 is not ...
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(2010-06-16)Department: BiochemistryAfter 30 years of research, p53 is recognized as one of the most frequently mutated genes in human cancer (Baker et al, 1989; Nigro et al, 1989; Momand et al, 2000; Daujat et la, 2001). To accomplish its tumor suppressive ...
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(2012-12-03)Department: Chemical and Physical BiologyiASPP (inhibitory member of the apoptosis stimulating protein of p53 family) is known to inhibit the important tumor suppressors p53 and p73. Indeed, iASPP is over-expressed in several cancer types and is associated with ...
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(2014-03-21)Department: Microbiology and ImmunologyRheumatoid arthritis is the most common serious autoimmune disease affecting almost one percent of the human population worldwide. Methotrexate is the most commonly used disease-modifying agent in patients with rheumatoid ...
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(2017-09-21)Department: Cell and Developmental BiologyTuberous Sclerosis Complex (TSC) is a pediatric disorder of dysregulated growth and differentiation caused by loss of function mutations in either the TSC1 or TSC2 genes, which regulate mTOR kinase activity. TSC causes ...
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(2015-11-13)Department: PathologymicroRNA (miRNA) are critical mediators of cellular signaling and regulate most biological processes. Thus, it is not surprising that miRNA dysregulation significantly contributes to tumorigenesis. In this dissertation, I ...