dc.creator | McDonald, Benjamin Seth | |
dc.date.accessioned | 2020-08-22T00:31:59Z | |
dc.date.available | 2010-04-12 | |
dc.date.issued | 2010-04-12 | |
dc.identifier.uri | https://etd.library.vanderbilt.edu/etd-04122010-010048 | |
dc.identifier.uri | http://hdl.handle.net/1803/12126 | |
dc.description.abstract | SiliSPECT, a multi-pinhole, multi-detector SPECT system, was designed to image targeted regions of rodents at sub-300 micron resolution with stationary data acquisition. High spatial resolution is achieved with thick silicon double-sided strip detectors (DSSDs) and 250 micron pinhole apertures. Each of the two camera heads contain two stacked DSSDs, which collect four multi-pinhole projection images simultaneously, enhancing the total detection efficiency and permitting reconstruction based on the synthetic collimator method. The DSSDs were evaluated for imaging low-energy photons, such as the emissions from iodine-125. Trigger uniformity was improved with an iterative trim adjustment algorithm. Detection efficiency, dead time, charge-sharing, and other detector characteristics were measured. The system sensitivity, resolution, multiplexing and magnification of the full system were assessed. A calibration method was implemented to estimate the geometrical parameters of the system. SiliSPECT was fully characterized and readied for tomographic imaging studies. | |
dc.format.mimetype | application/pdf | |
dc.subject | stacked detectors | |
dc.subject | synthetic collimator | |
dc.subject | silicon double-sided strip detectors | |
dc.subject | ASICS | |
dc.subject | Iodine-125 | |
dc.subject | Small-Animal SPECT | |
dc.title | Development of the SiliSPECT Small-Animal Imager | |
dc.type | dissertation | |
dc.contributor.committeeMember | M. Shane Hutson | |
dc.contributor.committeeMember | Will E. Johns | |
dc.contributor.committeeMember | Thomas E. Yankeelov | |
dc.contributor.committeeMember | John C. Gore | |
dc.type.material | text | |
thesis.degree.name | PHD | |
thesis.degree.level | dissertation | |
thesis.degree.discipline | Physics | |
thesis.degree.grantor | Vanderbilt University | |
local.embargo.terms | 2010-04-12 | |
local.embargo.lift | 2010-04-12 | |
dc.contributor.committeeChair | Todd E. Peterson | |