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Isolation and Characterization of Anti-malarial Compounds from a Natural Product Library

dc.creatorCarrell, Holly Marie
dc.date.accessioned2020-08-22T17:31:23Z
dc.date.available2013-07-29
dc.date.issued2013-07-29
dc.identifier.urihttps://etd.library.vanderbilt.edu/etd-07172013-085324
dc.identifier.urihttp://hdl.handle.net/1803/13115
dc.description.abstractMalaria is a disease caused by the parasite Plasmodium falciparum which kills 1-2.7 million people per year. Parasite resistance to widely available anti-malarial treatments such as Chloriquine is spreading rapidly, and current treatments for Chloroquine-resistant parasites tend to be unaffordable for people in the impoverished areas where malaria is endemic. Therefore, there is an increasing need for anti-malarial treatments that are easy to develop, effective, and inexpensive. In this study, we explore a novel source of anti-malarial probes by screening extracts from a library of cave actinomycetes. Using the â-hematin formation assay optimized in the Wright lab to screen for anti-malarial activity, coupled with LC-MS and 2D NMR techniques, we can isolate active compounds and determine their structure. In this project we identify the soy isoflavone Genistein as an active anti-malaria probe, and explores a new natural product resource that may be helpful in the continuing search for novel anti-malarial treatments.
dc.format.mimetypeapplication/pdf
dc.subjectMalaria
dc.subjectdrug discovery
dc.subjectnatural products
dc.subjectactinomycete library
dc.titleIsolation and Characterization of Anti-malarial Compounds from a Natural Product Library
dc.typethesis
dc.contributor.committeeMemberBrian Bachmann
dc.type.materialtext
thesis.degree.nameMS
thesis.degree.levelthesis
thesis.degree.disciplineChemistry
thesis.degree.grantorVanderbilt University
local.embargo.terms2013-07-29
local.embargo.lift2013-07-29
dc.contributor.committeeChairDavid Wright


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