dc.creator | Wu, Patrick | |
dc.date.accessioned | 2020-08-24T11:47:37Z | |
dc.date.available | 2022-01-17 | |
dc.date.issued | 2020-01-17 | |
dc.identifier.uri | https://etd.library.vanderbilt.edu/etd-01152020-134240 | |
dc.identifier.uri | http://hdl.handle.net/1803/15359 | |
dc.description.abstract | The phecode system was built upon the ICD-9-CM for PheWAS using the EHR. In this study, we developed and performed an initial evaluation of maps from ICD-10 and the ICD-10-CM codes to phecodes. We mapped ICD-10 and ICD-10-CM codes to phecodes using a number of methods and resources, such as concept relationships and explicit mappings from the Centers for Medicare & Medicaid Services, the UMLS, OHDSI, SNOMED-CT, and the NLM. We assessed the coverage of the maps at VUMC and UK Biobank. We also assessed the fidelity of the ICD-10-CM map in comparison to the gold-standard ICD-9-CM phecode map by investigating phenotype reproducibility and conducting PheWAS. These initial phecode maps allow researchers to leverage accumulated ICD-10 and ICD-10-CM data for PheWAS in the EHR. | |
dc.format.mimetype | application/pdf | |
dc.subject | electronic health record | |
dc.subject | genome-wide association study | |
dc.subject | phenome-wide association study | |
dc.subject | phenotyping | |
dc.title | Developing and Evaluating Mappings of ICD-10 and ICD-10-CM Codes to Phecodes | |
dc.type | thesis | |
dc.contributor.committeeMember | QiPing Feng | |
dc.contributor.committeeMember | Joshua C. Denny | |
dc.type.material | text | |
thesis.degree.name | MS | |
thesis.degree.level | thesis | |
thesis.degree.discipline | Biomedical Informatics | |
thesis.degree.grantor | Vanderbilt University | |
local.embargo.terms | 2022-01-17 | |
local.embargo.lift | 2022-01-17 | |
dc.contributor.committeeChair | Wei-Qi Wei | |