| dc.contributor.author | Du, Ling | |
| dc.contributor.author | Gong, Tao | |
| dc.contributor.author | Yao, Minghui | |
| dc.contributor.author | Dai, Henghua | |
| dc.contributor.author | Ren, Hong Gang | |
| dc.contributor.author | Wang, Haitao | |
| dc.date.accessioned | 2020-08-24T17:57:14Z | |
| dc.date.available | 2020-08-24T17:57:14Z | |
| dc.date.issued | 2019-06 | |
| dc.identifier.citation | Du, L., Gong, T., Yao, M., Dai, H., Ren, H. G., & Wang, H. (2019). Contribution of the polymorphism rs1800469 of transforming growth factor β in the development of myocardial infarction: meta-analysis of 5460 cases and 8413 controls (MOOSE-compliant article). Medicine, 98(26), e15946. https://doi.org/10.1097/MD.0000000000015946 | en_US |
| dc.identifier.issn | 0025-7974 | |
| dc.identifier.uri | http://hdl.handle.net/1803/15559 | |
| dc.description.abstract | Studies investigating the association between transforming growth factor (TGF-beta-509C/T, rs1800469) promoter polymorphism and myocardial infarction (MI) risk reported inconsistent results. The aim of our study was to assess the association between the 509C/T polymorphism of the TGF-beta gene (rs1800469) and MI risk.
A total of 5460 cases and 8413 controls in 7 case-control studies were incorporated in our current meta-analysis. The original studies were selected through searching the databases of the PubMed and EMBASE. The odds ratio (OR) and 95% confidence interval (95% CI) of TGF-beta 509C/T (rs1800469) for MI risk were applied to estimate the strength of the association.
Our results showed that T allele carriers had a 13% increased risk of MI, when compared with the C allele carriers (OR = 1.13, 95% CI: 1.00-1.27). In the subset analysis by the type of MI, significantly elevated risk of MI was associated with the homozygote TT and heterozygote C/T in no-AMI subjects, when compared with the CC homozygote carriers (OR = 1.12, 95% CI: 1.02-1.23).
Our meta-analysis shows that the polymorphism with homozygote TT and heterozygote C/T of TGF-beta 509C/T (rs1800469) is significantly associated with the increased risk of MI. | en_US |
| dc.language.iso | en_US | en_US |
| dc.publisher | Medicine | en_US |
| dc.rights | Copyright © 2019 the Author(s). Published by Wolters Kluwer Health, Inc.
This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0 | |
| dc.source.uri | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6617069/ | |
| dc.subject | cytokine gene polymorphisms | en_US |
| dc.subject | myocardial infarction | en_US |
| dc.subject | transforming growth factor beta | en_US |
| dc.title | Contribution of the polymorphism rs1800469 of transforming growth factor beta in the development of myocardial infarction: meta-analysis of 5460 cases and 8413 controls (MOOSE-compliant article) | en_US |
| dc.type | Article | en_US |
| CDType.cdtype.AnalyticFindingAid | 10.1097/MD.0000000000015946 | |
