dc.contributor.author | Sielatycki, J. Alex | |
dc.contributor.author | Saito, Masanori | |
dc.contributor.author | Yuasa, Masato | |
dc.contributor.author | Moore-Lotridge, Stephanie N. | |
dc.contributor.author | Uppuganti, Sasidhar | |
dc.contributor.author | Colazo, Juan M. | |
dc.contributor.author | Hysong, Alexander A. | |
dc.contributor.author | Robinette, J. Patton | |
dc.contributor.author | Okawa, Atsushi | |
dc.contributor.author | Yoshii, Toshitaka | |
dc.contributor.author | Schwartz, Herbert S. | |
dc.contributor.author | Nyman, Jeffry S. | |
dc.contributor.author | Schoenecker, Jonathan G. | |
dc.date.accessioned | 2019-02-04T19:40:09Z | |
dc.date.available | 2019-02-04T19:40:09Z | |
dc.date.issued | 2018-03-23 | |
dc.identifier.citation | Sielatycki, J. A., Saito, M., Yuasa, M., Moore‐Lotridge, S. N., Uppuganti, S., Colazo, J. M., … Schoenecker, J. G. (2018). Autologous chondrocyte grafting promotes bone formation in the posterolateral spine. JOR SPINE, 1(1), e1001. https://doi.org/10.1002/jsp2.1001 | en_US |
dc.identifier.issn | 2572-1143 | |
dc.identifier.other | 10.1002/jsp2.1001 | |
dc.identifier.uri | http://hdl.handle.net/1803/9373 | |
dc.description.abstract | Pseudarthrosis following spinal fusion remains problematic despite modern surgical and grafting techniques. In surgical spinal fusion, new bone forms via intramembranous and endochondral ossification, with endochondral ossification occurring in the hypoxic zones of the fusion bed. During bone development and fracture healing, the key cellular mediator of endochondral ossification is the hypertrophic chondrocyte given its ability to function in hypoxia and induce neovascularization and ossification. We therefore hypothesize that hypertrophic chondrocytes may be an effective bone graft alternative. | en_US |
dc.language.iso | en_US | en_US |
dc.subject | Bone Formation | en_US |
dc.subject | Bone-Morphogenic Protein | en_US |
dc.subject | Fracture Callus | en_US |
dc.subject | Hypertrophic Chondrocytes | en_US |
dc.subject | Iliac Crest Bone Graft | en_US |
dc.subject | Posterolateral Spinal Fusion | en_US |
dc.subject.lcsh | Orthopaedics | en_US |
dc.subject.lcsh | Ossification | en_US |
dc.subject.lcsh | Vascular endothelial growth factors | en_US |
dc.title | Autologous Chondrocyte Grafting Promotes Bone Formation in the Posterolateral Spine | en_US |
dc.type | Article | en_US |
dcterms.rights | © 2018 The Authors. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. | en_US |