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Patient Registries in Idiopathic Pulmonary Fibrosis
(American Journal of Respiratory and Critical Care Medicine, 2019-07-15)
Over the past decade, several large registries of patients with idiopathic pulmonary fibrosis (IPF) have been established. These registries are collecting a wealth of longitudinal data on thousands of patients with this ...
Oral Tresprostinil in Transition or as Add-on Therapy in Pediatric Pulmonary Arterial hypertension
(Pulmonary Circulation, 2019-07-12)
Treprostinil, a prostacyclin analogue, is approved for the treatment of pulmonary arterial hypertension (PAH) in adults. Transition from parenteral to oral treprostinil has been successfully accomplished in adults with PAH ...
Defects in COG-Mediated Golgi Trafficking Alter Endo-Lysosoma System in Human Cells
(FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 2019-07-03)
The conserved oligomeric complex (COG) is a multi-subunit vesicle tethering complex that functions in retrograde trafficking at the Golgi. We have previously demonstrated that the formation of enlarged endo-lysosomal ...
Defects in COG-Mediated Golgi Trafficking Alter Endo-Lysosoma System in Human Cells
(FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 2019-07-03)
The conserved oligomeric complex (COG) is a multi-subunit vesicle tethering complex that functions in retrograde trafficking at the Golgi. We have previously demonstrated that the formation of enlarged endo-lysosomal ...
Defects in COG-Mediated Golgi Trafficking Alter Endo-Lysosoma System in Human Cells
(FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 2019-07-03)
The conserved oligomeric complex (COG) is a multi-subunit vesicle tethering complex that functions in retrograde trafficking at the Golgi. We have previously demonstrated that the formation of enlarged endo-lysosomal ...
Identification and validation of biomarkers of persistent acute kidney injury: the RUBY study
(Intensive Care Medicine, 2020-02)
Purpose The aim of the RUBY study was to evaluate novel candidate biomarkers to enable prediction of persistence of renal dysfunction as well as further understand potential mechanisms of kidney tissue damage and repair ...
Bleeding Risk With Combination Intrapleural Fibrinolytic and Enzyme Therapy in Pleural Infection An International, Multicenter, Retrospective Cohort Study
(Chest, 2022-06-15)
BACKGROUND: Combination intrapleural fibrinolytic and enzyme therapy (IET) has been established as a therapeutic option in pleural infection. Despite demonstrated efficacy, studies specifically designed and adequately ...
Review Paper on Penetrating Brain Injury Ethical Quandaries in the Trauma Bay and Beyond
(Annals Of Surgery, 2023-01-28)
Objective:The aim of this review was to review the ethical and multidisciplinary clinical challenges facing trauma surgeons when resuscitating patients presenting with penetrating brain injury (PBI) and multicavitary trauma. ...
Pirfenidone Treatment in Individuals with Idiopathic Pulmonary Fibrosis: Impact of Timing of Treatment Initiation
(Annals of the American Thoracic Society, 2019-07)
To the Editor:
Idiopathic pulmonary fibrosis (IPF) is a debilitating, progressive, fatal, fibrosing lung disease (1, 2). Pirfenidone and nintedanib are oral antifibrotics with demonstrated efficacy in reducing lung ...
The Children's Respiratory and Environmental Workgroup (CREW) birth cohort consortium: design, methods, and study population
(Respiratory Reserarch, 2019-06-10)
BackgroundSingle birth cohort studies have been the basis for many discoveries about early life risk factors for childhood asthma but are limited in scope by sample size and characteristics of the local environment and ...