Search
Now showing items 11-16 of 16
Natural History of Cardiomyopathy in Adult Dogs With Golden Retriever Muscular Dystrophy
(Journal of the American Heart Association, 2019-08-20)
Background-Duchenne muscular dystrophy (DMD) is an X-linked disease that causes progressive muscle weakness. Affected boys typically die from respiratory or cardiac failure. Golden retriever muscular dystrophy (GRMD) is ...
Proteomics Profiling and Risk of New-Onset Atrial Fibrillation: Framingham Heart Study
(Journal of the American Heart Association, 2019-03-19)
Background-Prior studies relating proteomics markers to incident AF screened for limited numbers of proteins.
Methods and Results-We performed proteomics assays among participants from the Framingham Heart Study Offspring ...
Echocardiographic Detection of Occult Diastolic Dysfunction in Pulmonary Hypertension After Fluid Challenge
(Journal of the American Heart Association, 2019-09-23)
Background-Identification of occult diastolic dysfunction often requires invasive right heart catheterization with provocative maneuvers such as fluid challenge. Non-invasive predictors of occult diastolic dysfunction have ...
Interaction of alpha Carboxyl Terminus 1 Peptide With the Connexin 43 Carboxyl Terminus Preserves Left Ventricular Function After Ischemia-Reperfusion Injury
(Journal of the American Heart Association, 2019-08-20)
Background-alpha Carboxyl terminus 1 (alpha CT1) is a 25-amino acid therapeutic peptide incorporating the zonula occludens-1 (ZO-1)-binding domain of connexin 43 (Cx43) that is currently in phase 3 clinical testing on ...
Use of Genetic Variants Related to Antihypertensive Drugs to Inform on Efficacy and Side Effects
(Circulation, 2019-07-23)
Background: Drug effects can be investigated through natural variation in the genes for their protein targets. The present study aimed to use this approach to explore the potential side effects and repurposing potential ...
Low-Dose Aspirin for Primary Prevention of Cardiovascular Disease: Use Patterns and Impact Across Race and Ethnicity in the Southern Community Cohort Study
(2019-12-17)
Background
Data are limited on use patterns of low-dose aspirin and its role for primary prevention of cardiovascular disease (CVD) in different racial and ethnic groups.
Methods and Results
Overall, 65 231 ...