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Reactive Arial-based Antitachycardia Pacing Therapy Reduces Atrial Tachyarrhthmias
(PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY, 2019-07)
Background Reactive atrial-based antitachycardia pacing (rATP) aims to terminate atrial tachyarrhythmia/atrial fibrillation (AT/AF) episodes when they spontaneously organize to atrial flutter or atrial tachycardia; however, ...
Why has positive inotropy failed in chronic heart failure? Lessons from prior inotrope trials
(European Journal of Heart Failur, 2019-09)
Current pharmacological therapies for heart failure with reduced ejection fraction are largely either repurposed anti-hypertensives that blunt overactivation of the neurohormonal system or diuretics that decrease congestion. ...
Low-grade albuminuria in pulmonary arterial hypertension
(PULMONARY CIRCULATION, 2019-06)
Low-grade albuminuria, determined by the urinary albumin to creatinine ratio, has been linked to systemic vascular dysfunction and is associated with cardiovascular mortality. Pulmonary arterial hypertension is related to ...
Apolipoprotein E Genotype Modifies the Association Between Cardiac Output and Cognition in Older Adults
(Journal of the American Heart Association, 2019-08-06)
Background-Subtle reductions in cardiac output relate to lower cerebral blood flow, especially in regions where Alzheimer's disease pathology first develops. Apolipoprotein E (APOE)-epsilon 4 is a genetic susceptibility ...
Is There A Role for Electronic Cigarettes in Tobacco Cessation?
(Journal of the American Heart Association, 2019-06-18)
PCSK9 Inhibitor Use in the Real World: Data From the National Patient-Centered Research Network
(Journal of the American Heart Association, 2019-05-07)
Background-PCSK9 (proprotein convertase subtilisin/kexin type 9) inhibitors effectively lower LDL (low-density lipoprotein) cholesterol and have been shown to reduce cardiovascular outcomes in high-risk patients. We used ...
Trajectories of Blood Lipid Concentrations Over the Adult Life Course and Risk of Cardiovascular Disease and All-Cause Mortality: Observations From the Framingham Study Over 35 Years
(Journal of the American Heart Association, 2019-06-04)
Background-Elevated total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), triglycerides, and non-high-density lipoprotein cholesterol (non-HDL-C) and low high-density lipoprotein cholesterol (HDL-C) ...
Clinical Implications of the New York Heart Association Classification
(Journal of the American Heart Association, 2019-12-03)
Background
The New York Heart Association (NYHA) classification has served as a fundamental tool for risk stratification of heart failure (HF) and determines clinical trial eligibility and candidacy for drugs and devices. ...
Rationale and design of the EMPERIAL-Preserved and EMPERIAL-Reduced trials of empagliflozin in patients with chronic heart failure
(European Journal of Heart Failure, 2019-07)
Aims Heart failure ( HF) is associated with considerable symptom burden and impairment in physical functioning and quality of life. The sodium-glucose co-transporter 2 inhibitor empagliflozin reduced the risk of HF ...
Prevalence of Cardiovascular Disease Risk Factors in Childhood Glomerular Diseases
(Journal of the American Heart Association, 2019-07-16)
Background-Cardiovascular disease is a major cause of morbidity and mortality in children with chronic kidney disease. We sought to determine the prevalence of cardiovascular risk factors in children with glomerular disease ...