Division of Hematology / Oncology: Recent submissions
Now showing items 21-30 of 30
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(Arteriosclerosis Thrombosis and Vascular Biology, 2019-07)Objective- Activation of coagulation FXI (factor XI) by FXIIa (activated factor XII) is a prothrombotic process. The endothelium is known to play an antithrombotic role by limiting thrombin generation and platelet activation. ...
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(American Journal of Hematology, 2019-05)The efficacy of ibrutinib has been demonstrated in patients with chronic lymphocytic leukemia (CLL), including as first-line therapy. However, outcomes after ibrutinib discontinuation have previously been limited to ...
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(Clinical and Translational Radiation Oncology, 2019-09)Background: Patients with gastrointestinal cancers and brain metastases (BM) represent a unique and heterogeneous population. Our group previously published the Diagnosis-Specific Graded Prognostic Assessment (DS-GPA) for ...
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(JOURNAL OF THORACIC ONCOLOGY, 2019-08)Introduction: Inherited susceptibility to lung cancer risk in never-smokers is poorly understood. The major reason for this gap in knowledge is that this disease is relatively uncommon (except in Asians), making it difficult ...
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(Jounal of Hematology & Oncology, 2019-04-25)BackgroundLimited data is available to guide the choice of the conditioning regimen for patients with acute myeloid leukemia (AML) undergoing transplant with persistent disease.MethodsWe retrospectively compared outcome ...
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(SUPPORTIVE CARE IN CANCER, 2019-08)PurposeNeuroinflammation and central sensitization from cancer and its therapy may result in chronic systemic symptoms (CSS) such as fatigue, sleep disturbance, chronic widespread pain, mood disorders, neuropsychiatric ...
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(NUCLEIC ACIDS RESEARCH, 2019-05)The t(8;21) is one of the most frequent chromosomal translocations associated with acute myeloid leukemia (AML). We found that t(8; 21) AML were extremely sensitive to THZ1, which triggered apoptosis after only 4 h. We ...
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(LEUKEMIA, 2019-07)Risk stratification is critical in the care of patients with myelodysplastic syndromes (MDS). Approximately 10% have a complex karyotype (CK), defined as more than two cytogenetic abnormalities, which is a highly adverse ...
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(BREAST CANCER RESEARCH, 2019-07-05)BackgroundThe PI3K/AKT pathway is activated through PIK3CA or AKT1 mutations and PTEN loss in breast cancer. We conducted a phase II trial with an allosteric AKT inhibitor MK-2206 in patients with advanced breast cancer ...
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(FRONTIERS IN ONCOLOGY, 2019-07-10)Dosing regimens for antithymocyte globulin (ATG) and anti-CD52 antibody (alemtuzumab) for graft vs. host disease prophylaxis (GVHD) are empiric or weight-based, and do not account for individual patient factors. Recently, ...