Browsing by Title
Now showing items 10427-10446 of 17424
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(2008-03-13)Department: BiochemistryMultiple exocyclic DNA adducts arise from reactions of lipid and DNA peroxidation products with DNA bases. These endogenous lesions are mutagenic; therefore, monitoring adduct levels may provide a means of assessing genomic ...
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(2016-11-30)Department: PharmacologyHighly reactive acyclic levuglandin-like gamma-ketoaldehydes (gamma-KA, isoketals, or IsoKs) are formed as products of the isoprostane pathway of lipid peroxidation. IsoKs are known to covalently adduct ε-amino groups in ...
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(2014-04-19)Department: PharmacologyThe dietary polyphenol curcumin shows great promise as an anti-cancer and anti-inflammatory agent. While many cellular targets of curcumin have been identified, the chemical mechanisms whereby these targets are affected ...
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(2023-09-22)Department: Molecular Pathology & ImmunologyAtherosclerosis is an immune mediated hyperinflammatory disease driven by the retention and oxidation of low-density lipoprotein (LDL) in the vessel wall. The goal of this work was to determine how oxidized LDL (oxLDL) ...
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(2017-08-14)Department: Microbiology and ImmunologyOxidized low-density lipoprotein (oxLDL) is known to activate inflammatory responses in a variety of cells, especially macrophages and dendritic cells. Much of the oxLDL in circulation is complexed to antibodies, and these ...
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(Bmj-british Medical Journal, 2022-11-30)Objective To examine whether supraphysiological oxygen administration during surgery is associated with lower or higher postoperative kidney, heart, and lung injury. Design Observational cohort study. Setting 42 ...
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(2017-07-20)Department: Earth and Environmental SciencesI have conducted a modern precipitation and cave drip water analysis in Northern California and developed precisely dated, high-resolution records of stable oxygen (δ18O) and carbon (δ13C) isotope variability from a Lake ...
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(Vanderbilt University. Medical Center, 2007-05-13)A discussion of ventilation, oxygenation, and the role of PEEP.
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(NMR in Biomedicine, 2020-02)Skeletal muscle phosphorus-31 P-31 MRS is the oldest MRS methodology to be applied to in vivo metabolic research. The technical requirements of P-31 MRS in skeletal muscle depend on the research question, and to assess ...
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(Vanderbilt University, 2009)This paper introduces a computationally efficient bootstrap procedure for obtaining multiplicity-adjusted p-values in situations where multiple hypotheses are tested simultaneously. This new testing procedure accounts for ...
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(2007-04-06)Department: Cancer BiologyIntegration of receptor tyrosine kinase, integrin, and cadherin activities is crucial for normal cell growth, motility and adhesion. Here, we describe novel roles for p120 catenin (p120) and p190RhoGAP that coordinate ...
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(2015-12-09)Department: Cancer BiologyIn vertebrate epithelia, p120-catenin mediates E-cadherin stability and suppression of RhoA. Genetic ablation of p120 in various epithelial tissues typically causes striking alterations in tissue function and morphology. ...
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(Plos One, 2019-06-19)p63 is a transcriptional regulator of ectodermal development that is required for basal cell proliferation and stem cell maintenance. p73 is a closely related p53 family member that is expressed in select p63-positive basal ...
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(Michigan Law & Policy Review, 1996)Compensation for non-pecuniary losses is one of the most controversial components of tort liability. Newspaper headlines routinely feature occasionally extreme awards, such as the $2.9 million award to the women who spilled ...
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(Vanderbilt Medical Center, 2010-04-13)Richard Driessnack, M.D. is an Assistant Professor of Orthopaedics and Rehabilitation at Vanderbilt University Medical Center. The most common reason for putting off having hip or knee replacement is the fear of pain. ...
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(Vanderbilt University. Medical Center, 2008-08-21)The management of pain is a key element of the care of all patients-- ICU or not. Often providers have little understanding of the concepts and medications of pain management. This episode serves as an introduction
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(2015-04-10)Department: AnthropologyDuring the early-middle Holocene (7500-4000 BP) on the west coast of South America, the intense exploitation of a changing marine environment led to sedentism and an increase in social complexity (e.g., Moseley 1975, 1988; ...
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(2020-10-15)Department: Earth & Environmental SciencesThe Nasep and Huns Members of the Urusis Formation (Nama Group), southern Namibia, preserve some of the most diverse trace fossil assemblages known from the latest Ediacaran worldwide, including potentially the world’s ...
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(2012-07-30)Department: SpanishThis dissertation explores both the Hispanic and Anglo-American modernist traditions from the common standpoint of the palimpsest. Central to the diverse body of modernist writings is the appropriation of French symbolism, ...