Browsing by Author "Brian O. Bachmann"
Now showing items 1-20 of 44
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Mitchener, Michelle Marie (2017-12-06)Department: ChemistryPart A: Cyclooxygenase-2 (COX-2) oxygenates arachidonic acid (AA) and its ester analog, 2-arachidonoylglycerol (2-AG), to prostaglandins (PGs) and prostaglandin glyceryl esters (PG-Gs), respectively. Although the efficiency ...
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Goodwin, Cody Ray (2013-03-04)Department: ChemistryThis work explores the application of mass spectrometry-based multidimensional separations to metabolite analysis. The advent of a gas phase structure-based prioritization method for secondary metabolite prioritization and ...
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Butkiewicz, Mariusz (2014-07-28)Department: ChemistryQuantitative structure activity relationship (QSAR) modeling using high-throughput screening (HTS) data enables the development of predictive models for in silico screening. A cheminformatics framework termed BCL::ChemInfo ...
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Voehler, Markus Wolfgang (2007-12-27)Department: ChemistryThree constructs of African Swine Fever Virus DNA polymerase X (pol X) were expressed and purified. Buffers containing sodium acetate, sodium cacodylate or 0.5 M NaCl provided good solubility for the enzyme at micromolar ...
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Danneman, Michael William (2016-03-07)Department: ChemistryApplications of Chiral Amidine Catalysis Towards the Synthesis of Small Molecule Therapeutics and Recent Advances in Vicinal Diamine Synthesis Michael W. Danneman Dissertation Under the Direction of Professor Jeffrey N. ...
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Harry, Stephen Reese (2010-06-01)Department: ChemistryAs the field of chemical biology evolves, so does the development of novel bioanalytical techniques capable of accurately measuring biochemical composition and regulation. This dissertation explores three aspects of ...
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Birmingham, William Ross (2013-12-03)Department: BiochemistryEngineered biocatalysts have become increasingly sought after as replacements for individual chemical synthetic steps. However, their implementation in multistep sequences as biosynthetic pathways has proven to be a ...
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Phelan, Vanessa (2011-02-17)Department: ChemistryThe dissertation contained herein describes biosynthetic investigations of the peptide natural products K-26 and anthramycin. Unified by their peptidic nature, K 26 and anthramycin are potent biologically active metabolites ...
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Fulton, Mark Gallant (2019-07-22)Department: ChemistryThe metabotropic glutamate receptor 2/4 (mGlu2/4) heterodimer is a recently discovered receptor that displays unique pharmacology with respect to both mGlu2 and mGlu4 homodimeric receptors. Additionally, in vivo work has ...
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Beezer, Dain Bridgeon (2017-08-25)Department: ChemistryRegenerative medicine and drug delivery strategies require the use of advanced materials that can mimic the complex biological environment of native tissues. We present a series of advanced poly(glycidol) networks that are ...
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Adams, Nicholas Morgan (2014-03-19)Department: Chemical and Physical BiologySimple and rapid methods for detecting RNA biomarkers from patient samples are especially desirable in settings with limited access to laboratory resources and trained personnel. The focus of this dissertation is on the ...
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Nannemann, David Patrick (2011-04-06)Department: ChemistryNucleoside analogs comprise a large therapeutic class applied to the treatment of HIV, hepatitis, and other diseases. Their broad use and applicability are in contrast to their high manufacturing cost. Given the similarity ...
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Covington, Brett Casey (2018-08-27)Department: ChemistryNatural products remain valuable sources for modern drug discovery, yet natural product discovery is hindered by poor production in lab cultivated organisms and/or poor observability from complex microbial extracts. We ...
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Swartz, Joshua David (2011-09-15)Department: ChemistryThis dissertation focuses on two projects that attempt to solve two unique challenges. Biomimetic synthesis inspired by diatoms provides the mechanism for developing functional materials under ambient conditions. The goal ...
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Wepy, James Anthony (2019-01-02)Department: ChemistryLysophospholipase enzymes, lysophospholipase A1 (LYPLA1) and lysophospholipase A2 (LYPLA2), are serine hydrolases responsible for the metabolism of three separate classes of bioactive lipid substrates, including ...
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Hu, Yunfeng (2009-05-20)Department: ChemistryThe biosyntheses of benzodiazepines and nitrosugar containing natural products in actinomycetes were investigated. The first biosynthetic gene cluster of a benzodiazepine natural product was identified in the genome of the ...
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Morris, Caleb Bryce (2019-03-27)Department: ChemistryIon mobility (IM) is an important electrophoretic technique where gas-phase ions are separated by their collision cross section (CCS). Often, it is integrated with mass spectrometry, allowing separation of both ion size ...
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Shen, Bo (2010-04-02)Department: Chemistryα,β-Diamino acids and β-amino acids are important constituents in countless natural products. These atypical amino acids often display interesting and useful biological properties and have also been used as useful building ...
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Sease, Andrea Monique (2009-04-27)Department: ChemistryK-26 is an acidic tripeptide molecule with ACE inhibitory activity. It represents one of three distinct classes of unique phosphonate containing compounds found in nature. Previous work has found that unlike other C-P ...
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Al-Mestarihi, Ahmad H (2012-12-12)Department: ChemistryThis research work aims to provide biochemical characterization of the enzyme(s) responsible for deoxyaminosugar oxidation in several glycosylated natural products. The enzyme homologues ORF36 and RubN8 from the everninomicn ...