Browsing by Subject "breast cancer"
Now showing items 1-20 of 48
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(2012-04-13)Department: Nursing ScienceWhile researchers have found written emotional disclosure to be beneficial for psychological health, physical health, and overall functioning in certain populations, no one has definitively ascertained how or why this ...
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(2013-07-29)Department: Chemical and Physical BiologyWith the development of anti-cancer therapies that specifically target the tumor and its microenvironment, the current radiographic analysis of treatment response that uses one-dimensional changes in tumor size may not be ...
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(2010-04-16)Department: Biomedical EngineeringModality-independent elastography (MIE) is a method of elastography that reconstructs the elastic properties of tissue using images acquired under different loading conditions and a biomechanical model. Boundary conditions ...
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(2014-04-01)Department: ChemistryIon mobility-mass spectrometry (IM-MS) applies a gas-phase separation on the basis of structure prior to the MS, enabling separation of different types of biomolecules based on their gas-phase packing efficiencies. For ...
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(2012-05-03)Department: Cancer BiologyC/EBPbeta is a member of a family of basic-leucine zipper transcription factors. It has been shown to be a key regulator of growth and differentiation in the mammary gland. There are three different protein isoforms of ...
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(2022-05-16)Department: EpidemiologyChemotherapy can lead to various acute side effects and long-term toxicities, affecting treatment compliance, efficacy, and long-term outcomes. Growing evidence suggests that gastrointestinal (GI) microbiota may influence ...
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(2005-03-09)Department: ChemistryThe combination of laser capture microdissection (LCM) and matrix-assisted laser desorption/ionization mass spectrometry (MALDI MS) for protein profiling from specific cells of interest within heterogeneous tissue is ...
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(AMERICAN JOURNAL OF EPIDEMIOLOGY, 2019-06)The Consortium of Metabolomics Studies (COMETS) was established in 2014 to facilitate large-scale collaborative research on the human metabolome and its relationship with disease etiology, diagnosis, and prognosis. COMETS ...
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(2015-03-11)Department: Biomedical EngineeringA clinical need exists for improved methods to identify cancer patients with tumors prone to drug resistance, and prescribe effective alternative therapies. Cellular metabolism is a powerful marker of tumor response to ...
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Development of prognostic model for breast cancer in Shanghai Breast Cancer Survival Study (SBCSS) (2015-07-23)Department: BiostatisticsWe developed prognostic models to predict five-year overall survival (OS), ten-year overall survival (OS), and five-year relapse-free survival (RFS) from Shanghai Breast Cancer Survival Study (SBCSS). SBCSS is a large, ...
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(2019-08-20)Department: EpidemiologyOne of the well-established risk factors for breast cancer (BC) is high level of endogenous estrogen, which could be influenced by both genetic and non-genetic factors. Few studies have investigated estrogen related ...
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(Intenational Journal of Cancer, 2020-03-01)We previously identified a novel breast cancer susceptibility variant on chromosome 4q31.22 locus (rs1429142) conferring risk among women of European ancestry. Here, we report replication of findings, validation of the ...
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(2016-11-23)Department: Biomedical EngineeringCancer immunotherapies, which seek to arm the patient’s own immune system for personalized therapy, are a promising option for effective elimination of tumors. Focused ultrasound (FUS) is one propitious method for generating ...
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(Molecular Genetics & Genome Medicine, 2019-06)BackgroundEpidemiological studies consistently indicate that alcohol consumption is an independent risk factor for female breast cancer (BC). Although the aldehyde dehydrogenase 2 (ALDH2) polymorphism (rs671: Glu>Lys) has ...
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(2022-07-11)Department: EpidemiologyTo date, genome-wide association studies (GWAS) have identified common genetic variants at approximately 200 loci for breast cancer risk. GWAS have been predominately conducted among women of European ancestry, and the ...
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(2016-03-16)Department: EpidemiologyTriple-negative breast cancer (TNBC), which is characterized by minimal or lack of expression of estrogen receptors and progesterone receptors, and the absence of overexpression of human epidermal growth factor 2 ...
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(2021-12-20)Department: Cancer BiologyBreast cancer cells frequently home to the bone marrow, where they encounter signals that promote survival and quiescence or stimulate their proliferation. However, our mechanistic understanding of bone dissemination and ...
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(2019-11-14)Department: Cancer BiologyRIG-I is a cytoplasmic RNA helicase expressed in most cells of the body, functioning to sense viral oligonucleotide motifs then activate innate immune responses to combat viral infection. RIG-I expression and activity is ...
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(2010-04-12)Department: Biomedical EngineeringImaging protocols for detection of breast cancer metastases to bone in clinical imaging have long been standardized, but to date small animal imaging still uses a variety of imaging modalities and protocols. Although imaging ...
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(2017-04-17)Department: Biomedical InformaticsPatient care is complex and imperfect. Understanding and improving patient care requires clinical datasets and scientific methodology. We designed a set of methods to characterize the state of patient care and identify ...