Browsing by Subject "diabetes"
Now showing items 1-20 of 38
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(2004-04-09)Department: Chemical EngineeringMethylglyoxal (MG) is a toxic compound which is produced in cells as a byproduct of glycolysis. Recently, the compound has been suggested as a damaging agent in batch cultures of production cell lines. In the current ...
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(2006-10-09)Department: Microbiology and ImmunologySelf-reactive B lymphocytes are frequently produced as a consequence of B cell antigen receptor rearrangement. Autoreactive B cells that are not eliminated or inactivated by tolerance mechanisms survive and mature in the ...
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(2014-04-01)Department: ChemistryIon mobility-mass spectrometry (IM-MS) applies a gas-phase separation on the basis of structure prior to the MS, enabling separation of different types of biomolecules based on their gas-phase packing efficiencies. For ...
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(AMERICAN JOURNAL OF EPIDEMIOLOGY, 2019-06)The Consortium of Metabolomics Studies (COMETS) was established in 2014 to facilitate large-scale collaborative research on the human metabolome and its relationship with disease etiology, diagnosis, and prognosis. COMETS ...
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(2017-07-20)Department: ChemistryPolymeric nanoparticles have historically been shown to be valuable tools for the solubilization and delivery of small molecule hydrophobic drugs. However, most systems do not address obstacles associated with off-target ...
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(2015-11-23)Department: Biomedical EngineeringPeripheral arterial disease (PAD) affects millions of individuals and increases the risk of myocardial infarction, stroke, and mortality. Compared to the general population, diabetic patients have a four times greater risk ...
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(2012-12-11)Department: Molecular Physiology and BiophysicsInsulin secretion is the natural response to hyperglycemia, and it is crucial to maintain glucose homeostasis in healthy individuals. Impairment in this regulation eventually results in Type-2 diabetes. From the perspective ...
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(2010-09-15)Department: Hearing and Speech SciencesThis project is concerned with the relationship between type-1 diabetes and auditory pathology. In this dissertation I compared hearing sensitivity, cochlear function, and peripheral auditory neural function (afferent and ...
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(2013-10-01)Department: Cell and Developmental BiologyCELL AND DEVELOPMENTAL BIOLOGY Examination of Hnf6 and downstream effectors in postnatal endocrine function Kathryn D. Henley Dissertation under the direction of Professor Maureen Gannon The pancreas is an ...
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(2015-10-20)Department: Molecular Physiology and BiophysicsAnalysis of MafB-/- mice suggested that this transcription factor was essential to islet α- and β-cell formation during development, although the postnatal physiological impact could not be studied because these mutants ...
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(2010-12-17)Department: Microbiology and ImmunologyCommon, complex diseases are not caused by a single gene mutation but rather have genetic and environmental components. As a subset, autoimmune diseases also possess robust gene expression signatures that have both genetic ...
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(2015-10-20)Department: Molecular Physiology and BiophysicsDiabetes is characterized by excess levels of glucose and lipid in the blood, which have been proposed to directly and negatively impact islet β cells, exacerbating symptoms and promoting disease progression. Our understanding ...
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(2013-04-18)Department: Biomedical InformaticsExisting research on evaluating patients’ interests has focused on user surveys, which encounter problems such as high financial and time costs as well as a low user participation rate. To address these problems, this study ...
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(2015-05-28)Department: Molecular Physiology and BiophysicsPdx1 is a transcription factor of fundamental importance to pancreas formation and adult islet β-cell function. However, little is known regarding its role in mature β-cells or the positive- and negative-acting coregulators ...
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(2017-12-08)Department: Medicine, Health, and SocietyWhile healthcare research has examined how social and emotional factors complicate treatment of chronic disease, practitioners often have few resources to assess and address the impact of non-biological influences on patient ...
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(JOURNAL OF BIOLOGICAL CHEMISTRY, 2019-06-21)Mouse studies linking adropin, a peptide hormone encoded by the energy homeostasis-associated (ENHO) gene, to biological clocks and to glucose and lipid metabolism suggest a potential therapeutic target for managing diseases ...
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(2015-07-16)Department: Molecular Physiology and BiophysicsReduced pancreatic β cell mass is a hallmark of diabetes, which makes the ability to increase or restore β cell mass a major therapeutic goal. While testing the hypothesis that increased endothelial cell signaling would ...
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(2021-08-16)Department: Chemical EngineeringBiochemical methods to quantify gene transcript, enzyme, and metabolite levels are widely used to assess metabolic pathway regulation. Though informative and even vital in some contexts, static measurements of biomolecule ...
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(2015-03-25)Department: Cell and Developmental BiologyAs diabetes continues to affect millions of people within the United States, identification of novel factors that may enhance beta-cell proliferation and mass regeneration in vivo is critical. Our lab previously demonstrated ...
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(2014-04-17)Department: Molecular Physiology and BiophysicsThe roles for ascorbic acid (ASC) in regulation of its transporter, in neurotransmitter synthesis, and in brain endothelial cell barrier permeability were investigated in the brain. First, during mouse development, levels ...