dc.contributor.author | Ferguson, Michael A. | |
dc.contributor.author | Lim, Chun | |
dc.contributor.author | Cooke, Danielle | |
dc.contributor.author | Darby, R. Ryan | |
dc.contributor.author | Wu, Ona | |
dc.contributor.author | Rost, Natalia S. | |
dc.contributor.author | Corbetta, Maurizio | |
dc.contributor.author | Grafman, Jordan | |
dc.contributor.author | Fox, Michael D. | |
dc.date.accessioned | 2020-06-25T19:48:41Z | |
dc.date.available | 2020-06-25T19:48:41Z | |
dc.date.issued | 2019-08-02 | |
dc.identifier.citation | Ferguson, M.A., Lim, C., Cooke, D. et al. A human memory circuit derived from brain lesions causing amnesia. Nat Commun 10, 3497 (2019). https://doi.org/10.1038/s41467-019-11353-z | en_US |
dc.identifier.issn | 2041-1723 | |
dc.identifier.uri | http://hdl.handle.net/1803/10071 | |
dc.description.abstract | Human memory is thought to depend on a circuit of connected brain regions, but this hypothesis has not been directly tested. We derive a human memory circuit using 53 case reports of strokes causing amnesia and a map of the human connectome (n = 1000). This circuit is reproducible across discovery (n = 27) and replication (n = 26) cohorts and specific to lesions causing amnesia. Its hub is at the junction of the presubiculum and retrosplenial cortex. Connectivity with this single location defines a human brain circuit that incorporates > 95% of lesions causing amnesia. Lesion intersection with this circuit predicts memory scores in two independent datasets (N1 = 97, N2 = 176). This network aligns with neuroimaging correlates of episodic memory, abnormalities in Alzheimer's disease, and brain stimulation sites reported to enhance memory in humans. | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | NATURE COMMUNICATIONS | en_US |
dc.rights | This is an open access article distributed under the terms of the Creative Commons CC BY license, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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dc.source.uri | https://www.nature.com/articles/s41467-019-11353-z | |
dc.subject | EPISODIC MEMORY | en_US |
dc.subject | DEFAULT-MODE | en_US |
dc.subject | ALZHEIMERS-DISEASE | en_US |
dc.subject | NEUROLOGICAL SYMPTOMS | en_US |
dc.subject | HIPPOCAMPAL-FORMATION | en_US |
dc.subject | NETWORK LOCALIZATION | en_US |
dc.subject | CORTEX | en_US |
dc.subject | STIMULATION | en_US |
dc.subject | RETRIEVAL | en_US |
dc.subject | ANATOMY | en_US |
dc.title | A human memory circuit derived from brain lesions causing amnesia | en_US |
dc.type | Article | en_US |
dc.identifier.doi | 10.1038/s41467-019-11353-z | |