| dc.contributor.author | Jerrell, Rachel J. | |
| dc.contributor.author | Parekh, Aron | |
| dc.date.accessioned | 2020-08-06T21:21:33Z | |
| dc.date.available | 2020-08-06T21:21:33Z | |
| dc.date.issued | 2019-06 | |
| dc.identifier.issn | 2352-3409 | |
| dc.identifier.uri | http://hdl.handle.net/1803/10270 | |
| dc.description.abstract | Actomyosin contractility can promote extracellular matrix (ECM) degradation by invadopodia in cancer cells. However, we previously found that inhibiting myosin light chain kinase (MLCK) with siRNA did not change force generation by the head and neck squamous cell carcinoma (HNSCC) cell line SCC-61. We provide data here that this targeted method of MLCK knockdown (KD) resulted in a significant increase in the amount of ECM degradation, number of actively degrading invadopodia, and the number of total invadopodia formed. These data are related to the research article entitled "Matrix rigidity differentially regulates invadopodia activity through ROCK1 and ROCK2" Jerrell and Parekh, 2016. (C) 2019 The Author(s). Published by Elsevier Inc. | en_US |
| dc.description.sponsorship | Research reported in this publication was previously supported by the National Institutes of Health grant K25CA143412 from the National Cancer Institute to A.P. Additional support was provided at the time by the Vanderbilt Clinical and Translational Science Award UL1TR000445 from the National Center for Advancing Translational Sciences and resources from the Vanderbilt Advanced Computing Center for Research and Education. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health or National Center for Advancing Translational Sciences. Current support was provided by the Research Scholar Grant RSG-15-226-01-CSM from the American Cancer Society to A.P. | en_US |
| dc.language.iso | en_US | en_US |
| dc.publisher | Data in Brief | en_US |
| dc.rights | ©2019 The Author(s). Published by Elsevier Inc. This is an openaccess article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). | |
| dc.source.uri | https://reader.elsevier.com/reader/sd/pii/S2352340919302902?token=D50E1E1043EFABB0B04CA2387306517375A537DEBF8572732BBDF146CBCE338DB11B95B7A27AF56A88456C598F69342A | |
| dc.subject | Cancer | en_US |
| dc.subject | Invasion | en_US |
| dc.subject | Invadopodia | en_US |
| dc.subject | MLCK | en_US |
| dc.subject | Contractility | en_US |
| dc.title | Data on the negative regulation of invadopodia activity by MLCK | en_US |
| dc.type | Article | en_US |
| dc.identifier.doi | 10.1016/j.dib.2019.103939 | |
