dc.creator | Zachman, Angela Laurie | |
dc.date.accessioned | 2020-08-22T00:19:43Z | |
dc.date.available | 2016-04-07 | |
dc.date.issued | 2014-04-07 | |
dc.identifier.uri | https://etd.library.vanderbilt.edu/etd-03312014-183105 | |
dc.identifier.uri | http://hdl.handle.net/1803/11870 | |
dc.description.abstract | Peripheral artery disease (PAD) is characterized by platelet activation and aggregation on arterial walls, resulting in vessel occlusion and ischemia. To treat PAD, it is desirable to have a high degree of angiogenesis to promote collateral blood vessel formation, with a low degree of inflammation to minimize plaque development. However, these two processes are intrinsically linked and difficult to uncouple. Therefore, the overarching goal of this research was to develop a biomaterial system that enables controlled, dual delivery of pro-angiogenic and anti-inflammatory peptides in minimally-invasive way. To achieve the goal, a peptide-loaded injectable scaffold system was developed and tested in a mouse model of PAD. In addition, the mechanism of peptide-mediated regulation of angiogenesis and inflammation was elucidated. By regulating pathways involved in inflammation and angiogenesis independently, this dual peptide-loaded injectable scaffold system may significantly improve recovery of ischemic tissues in patients with PAD. | |
dc.format.mimetype | application/pdf | |
dc.subject | inflammation | |
dc.subject | injectable polymer | |
dc.subject | atherosclerosis | |
dc.subject | peripheral artery disease | |
dc.subject | peptide | |
dc.subject | angiogenesis | |
dc.title | Peptide-functionalized Polymers Regulating Angiogenesis and Inflammation in Peripheral Artery Disease | |
dc.type | dissertation | |
dc.contributor.committeeMember | Pampee P. Young, M.D., Ph.D. | |
dc.contributor.committeeMember | Craig L. Duvall, Ph.D. | |
dc.contributor.committeeMember | Melissa C. Skala, Ph.D. | |
dc.contributor.committeeMember | Scott A. Guelcher, Ph.D. | |
dc.type.material | text | |
thesis.degree.name | PHD | |
thesis.degree.level | dissertation | |
thesis.degree.discipline | Biomedical Engineering | |
thesis.degree.grantor | Vanderbilt University | |
local.embargo.terms | 2016-04-07 | |
local.embargo.lift | 2016-04-07 | |
dc.contributor.committeeChair | Hak-Joon Sung, Ph.D. | |