dc.creator | Woodward, Emily Jean | |
dc.date.accessioned | 2020-08-22T21:03:43Z | |
dc.date.available | 2007-10-09 | |
dc.date.issued | 2006-10-09 | |
dc.identifier.uri | https://etd.library.vanderbilt.edu/etd-09182006-172759 | |
dc.identifier.uri | http://hdl.handle.net/1803/14172 | |
dc.description.abstract | Self-reactive B lymphocytes are frequently produced as a consequence of B cell antigen receptor rearrangement. Autoreactive B cells that are not eliminated or inactivated by tolerance mechanisms survive and mature in the periphery. In the spleen, the marginal zone serves as a reservoir for autoreactive B lymphocytes. Marginal zone B cells are known for their rapid and robust responses to T-independent stimuli and serve functions in both the innate and adaptive arms of the immune system. Anti-insulin transgenic B cells are preferentially selected into the marginal zone and are functionally anergic. These cells provide an opportunity to study how autoreactive B cells mature into the marginal zone subset. Using the anti-insulin transgenic model, we find that multiple factors influence marginal zone B cell maturation. These elements include B cell receptor specificity, lineage regulators such as Notch2, and a differentially expressed transcriptional profile. Understanding the processes that regulate marginal zone B cell maturation and how anergy is maintained in this population will impact our ability to manage these cells in host defense and autoimmune disease. | |
dc.format.mimetype | application/pdf | |
dc.subject | autoimmunity | |
dc.subject | diabetes | |
dc.subject | immunoglobulin | |
dc.subject | zinc finger protein | |
dc.subject | marginal zone | |
dc.subject | B cell | |
dc.subject | autoreactive | |
dc.subject | Notch2 | |
dc.title | Autoreactive B cell development in the periphery | |
dc.type | dissertation | |
dc.contributor.committeeMember | Eugene M. Oltz | |
dc.contributor.committeeMember | Mark R. Boothby | |
dc.contributor.committeeMember | P. Anthony Weil | |
dc.contributor.committeeMember | James W. Thomas | |
dc.type.material | text | |
thesis.degree.name | PHD | |
thesis.degree.level | dissertation | |
thesis.degree.discipline | Microbiology and Immunology | |
thesis.degree.grantor | Vanderbilt University | |
local.embargo.terms | 2007-10-09 | |
local.embargo.lift | 2007-10-09 | |
dc.contributor.committeeChair | Wasif N. Khan | |