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Chemical Control of Mosquitoes and the Pesticide Treadmill: A Case for Photosensitive Insecticides as Larvicides
(Insects, 2022-11-28)
Simple Summary Mosquitoes transmit disease, and over the past century, mosquito control has mostly relied on chemical insecticides that target the adult life stage. We review methods of mosquito control and argue that ...
Clinical characteristics and electrophysiologic properties of SCN5A variants in fever-induced Brugada syndrome
(Ebiomedicine, 2022-12)
Background Brugada syndrome (BrS) is a severe inherited arrhythmia syndrome that can be unmasked by fever.Methods A multicentre clinical analysis was performed in 261 patients diagnosed with fever-induced BrS, including ...
Mitofusins Mfn1 and Mfn2 Are Required to Preserve Glucose- but Not Incretin-Stimulated beta-Cell Connectivity and Insulin Secretion
(Diabetes, 2022-07)
Mitochondrial glucose metabolism is essential for stimulated insulin release from pancreatic beta-cells. Whether mitofusin gene expression, and hence, mitochondrial network integrity, is important for glucose or incretin ...
Application of a Human Blood Brain Barrier Organ-on-a-Chip Model to Evaluate Small Molecule Effectiveness against Venezuelan Equine Encephalitis Virus
(Viruses-basel, 2022-12-15)
The blood brain barrier (BBB) is a multicellular microenvironment that plays an important role in regulating bidirectional transport to and from the central nervous system (CNS). Infections by many acutely infectious viruses ...
Diverse environmental perturbations reveal the evolution and context-dependency of genetic effects on gene expression levels
(Genome Research, 2022-10)
There is increasing appreciation that, in addition to being shaped by an individual's genotype and environment, most complex traits are also determined by poorly understood interactions between these two factors. So-called ...