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Cardiolipin-Dependent Properties of Model Mitochondrial Membranes from Molecular Simulations
(Biophysical Journal, 2019-08)
Cardiolipin is an anionic lipid found in the mitochondrial membranes of eukaryotes ranging from unicellular microorganisms to metazoans. This unique lipid contributes to various mitochondrial functions, including metabolism, ...
Multiplexed Adaptive RT-PCR Based on L-DNA Hybridization Monitoring for the Detection of Zika, Dengue, and Chikungunya RNA
(Scientific Reports, 2019-08-06)
Reverse transcription polymerase chain reaction (RT-PCR) is the gold standard for the molecular diagnosis of many infectious diseases, including RNA viruses, but is generally limited to settings with access to trained ...
Identification of drug-specific public TCR driving severe cutaneous adverse reactions
(Nature Communications, 2019-08-08)
Drug hypersensitivity such as severe cutaneous adverse reactions (SCAR), including Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN), could be life-threatening. Here, we enroll SCAR patients to investigate ...
Essentialism and Enhancing Healthcare Experiences: The Strategic Pursuit of "Less"
(Journal of Patient Experience, 2019-06)
Mean Coronary Cross-Sectional Area as a Measure of Arterial Remodeling Using Noncontrast CT Imaging in Persons With HIV
(Journal Of The American Heart Association, 2022-12-06)
BackgroundPersons with HIV have a higher prevalence of coronary artery disease compared with their HIV-negative counterparts. Earlier identification of subclinical atherosclerosis may provide a greater opportunity for ...
Occupational demands associated with rotator cuff disease surgery in the UK Biobank
(Scand J Work Environ Health, 2022-10)
Objectives Physically-demanding occupations may increase rotator cuff disease (RCD) risk and need for sur- gery. We linked a job-exposure matrix (JEM) to the UK Biobank cohort study to measure physical occupational exposures ...
Post-COVID-19 human memory impairment: A PRISMA-based systematic review of evidence from brain imaging studies
(Frontiers In Aging Neuroscience, 2022-12-09)
Many people with coronavirus disease 2019 (COVID-19) report varying degrees of memory impairment. Neuroimaging techniques such as MRI and PET have been utilized to shed light on how COVID-19 affects brain function in humans, ...
Reforming Reimbursement for the US Food and Drug Administration's Accelerated Approval Program to Support State Medicaid Programs
(Jama Health Forum, 2022-11-18)
IMPORTANCE The US Food and Drug Administration (FDA) has an accelerated approval program that has become the subject of scholarly attention and criticism, not only for the FDA's oversight of the program but also for its ...
Salidroside inhibits the proliferation and migration of gastric carcinoma cells and tumor growth via the activation of ERS-dependent autophagy and apoptosis
(RSC Advances, 2019-08-18)
The endoplasmic reticulum stress (ERS)-induced autophagy and apoptosis are favorable for the suppression of many cancer types. Salidroside (Salid) has been proven to be capable of inducing the apoptosis of many cancer ...
Microbiota-derived acetate protects against respiratory syncytial virus infection through a GPR43-type 1 interferon response
(Nature Communications, 2019-07-22)
Severe respiratory syncytial virus (RSV) infection is a major cause of morbidity and mortality in infants <2 years-old. Here we describe that high-fiber diet protects mice from RSV infection. This effect was dependent on ...