Molecular Seismology: An inverse problem in nanobiology.

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Title:	Molecular Seismology: An inverse problem in nanobiology.
Author:	Boczko, Erik M. Hinow, Peter
Abstract:	The density profile of an elastic fiber like DNA will change in space and time as ligands associate with it. This observation affords a new direction in single molecule studies provided that density profiles can be measured in space and time. In fact, this is precisely the objective of seismology, where the mathematics of inverse problems have been employed with success. We argue that inverse problems in elastic media can be directly applied to biophysical problems of fiber-ligand association, and demonstrate that robust algorithms exist to perform density reconstruction in the condensed phase.
Subject:	DNA-protein interactions Wave equation Single molecule studies Inverse problems (Differential equations) DNA-ligand interactions Density inversion DNA binding kinetics
URI:	http://hdl.handle.net/1803/153
Date:	2006-09-12